In the present scenario, with the increasing incidence of diseases, the number of studies for its cure and prevention is also increasing. It is very important to study the potential of the new drug. Recently, a research team led by Christopher C.W. Hughes, Professor of Molecular Biology and Biochemistry, University of California, Irvine, effectively created a multiple vascularized micro-organs on a 96-well plate.
Hughes and Duc T. T. Phan demonstrated in their study that these minuscule tissues are to a great extent superior at mimic human drug responses in comparison to the earlier model systems.
The researchers wrote in their study, “There is an increasing understanding that intricate three-dimensional organs are not depicted precisely by the monolayers of a single type of cells, which a standard protocol for screening many drugs.”
Hughes said, “We illustrate an arrayed version of the interface that integrates several vascularized micro-organs on a standard 96-well plate. Each of the vascularized micro-organs can be approached independently and the flow across the micro-organ is operated by the hydrostatic pressure. The interface is simpler to use, no need of valves or external pumps, and is extremely reproducible.”
The research team has also illustrated how the flow of a blood substitute across the vascular system they produced can transport nutrients to numerous types of tissues, including pancreas, heart, brain, and several tumors.
Hughes further said, “This is actually a distinctive platform. We have reconstructed in a dish the vital element universal to all tissues that for their survival they are dependent on the blood vessel. This attribute is absent in all formerly illustrated in-vitro organ cultures.”
The team also successfully established a functional vascularized micro-tumor in a 96-well plate system and exhibited its potential for screening of an anti-cancer drug.
Working with a human colon cancer and a group of Food and Drug Administration-approved anti-cancer drugs, the researcher found that the vascularized micro-tumor platform could precisely recognize the vessels that deliver the drugs, the drugs that target the tumor cells, or both.
Thus, this organ-on-chip system can provide various insights and take the drug screening research on the next level. Feel free to share your thoughts.